Article
2-Aminopurine overrides a late telophase delay created by ectopic expression of the PITSLRE beta 1 protein kinase.
Biochemical and biophysical research communications - 30 Mar 1994
Xiang J, Lahti J M, Kidd V J
Abstract excerpt
Minimal overexpression of the PITSLRE beta 1 protein kinase in CHO cells leads to a marked delay in late mitosis. We have previously shown that this delay is characterized by the presence of substantially increased numbers of tubulin midbodies, inhibition of cytokinesis, and numerous multinucleated and micronucleated cells. Others have shown that the protein kinase inhibitor 2-aminopurine (2-AP) is capable of...
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