Article
Constitutive activation of the collagenase promoter in recessive dystrophic epidermolysis bullosa fibroblasts: role of endogenously activated AP-1.
Experimental cell research - 1 Apr 1994
Unemori E N, Mauch C, Hoeffler W, Kim Y, Amento E P, Bauer E A
Abstract excerpt
Recessive dystrophic epidermolysis bullosa (RDEB) is a mutilating disease of the skin characterized by recurrent blistering and erosions that result from compromised integrity of the basement membrane zone. In this study, fibroblasts derived from the skin of RDEB patients were characterized for expression of the major metalloproteinases, particularly interstitial collagenase. Consistent with previous reports on...
Topics
- Cells, Cultured
- Collagenases
- Epidermolysis Bullosa Dystrophica
- Gene Expression Regulation
- Genes, Recessive
- Humans
- Matrix Metalloproteinase 3
- Metalloendopeptidases
- Phenotype
- Promoter Regions, Genetic