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Article

Identification and characterization of the Treponema pallidum tpn50 gene, an ompA homolog.

Infection and immunity - 1 Mar 1994

Hardham J M, Stamm L V

Abstract excerpt

Treponema pallidum is a pathogenic spirochete that has no known genetic exchange mechanisms. In order to identify treponemal genes encoding surface and secreted proteins, we carried out TnphoA mutagenesis of a T. pallidum genomic DNA library in Escherichia coli. Several of the resulting clones expressed enzymatically active T. pallidum-alkaline phosphatase fusion proteins. The DNA sequence of the 5' portion of a...

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Identifiers

PMID: 8112835
DOI: 10.1128/iai.62.3.1015-1025.1994
PMCID: PMC186218

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