Article
Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994
Boyd E F, Nelson K, Wang F S, Whittam T S, Selander R K
Abstract excerpt
Nucleotide sequences of the mdh gene encoding the metabolic enzyme malate dehydrogenase (MDH) were determined for 44 strains representing the major lineages of Escherichia coli and the eight subspecies of Salmonella enterica. Sequence diversity was four times greater in S. enterica than in E. coli, and in both species the rate of amino acid substitution was lower in the NAD(+)-binding domain than in the catalytic...
Topics
- Adaptation, Physiological
- Alleles
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Escherichia coli
- Isoenzymes
- Malate Dehydrogenase
- Molecular Sequence Data
- Polymerase Chain Reaction