Huntington's disease: predictive testing and the molecular genetics laboratory.

doi:10.1111/j.1399-0004.1993.tb04441.x

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Article

Huntington's disease: predictive testing and the molecular genetics laboratory.

Clinical genetics - 1 Mar 1993

Lazarou L P, Meredith A L, Myring J M, Tyler A, Morris M, Ball D M, Harper P S

Abstract excerpt

We describe the laboratory-related aspects of a series of 40 completed presymptomatic tests for Huntington's disease, using linked DNA markers. Pedigree structure and marker heterozygosity are shown to be important factors, both in the number of laboratory analyses required to give an informative...

Topics

Adult
Algorithms
Alleles
Diagnostic Errors
Female
Genetic Linkage
Genetic Markers
Genotype
Humans
Huntington Disease
Male
Middle Aged
Pedigree
Pilot Projects
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Risk Factors

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