Article
Quantification of oncogene dosage in tumours by simultaneous dual-label hybridization.
Oncogene - 1 Jan 1993
Stickland J E, Tomlinson I P, Ramshaw A L, Bromley L, Potter C G, McGee J O
Abstract excerpt
Gene amplification and allele loss occur in a variety of human tumours and some have prognostic value. Therefore, techniques which facilitate detection and quantification of gene dosage could have wide applicability in cancer research. Using the INT-2 gene as a model system, a quantitative procedure has been developed for measuring gene copy number using dual-label hybridization to DNA dot blots. A probe specific...
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