Article
Quantification of oncogene dosage in tumours by simultaneous dual-label hybridization.
Oncogene - 1 Jan 1993
Stickland J E, Tomlinson I P, Ramshaw A L, Bromley L, Potter C G, McGee J O
Abstract excerpt
Gene amplification and allele loss occur in a variety of human tumours and some have prognostic value. Therefore, techniques which facilitate detection and quantification of gene dosage could have wide applicability in cancer research. Using the INT-2 gene as a model system, a quantitative proced...
Topics
- Alleles
- Breast Neoplasms
- DNA, Neoplasm
- Female
- Fibroblast Growth Factor 3
- Fibroblast Growth Factors
- Gene Amplification
- Gene Deletion
- Humans
- Nucleic Acid Hybridization
- Oncogenes
- Polymorphism, Restriction Fragment Length
- Proto-Oncogene Proteins