Article
Evolution of transcription-regulating proteins by enzyme recruitment: molecular models for nitrogen metabolite repression and ethanol utilisation in eukaryotes.
Gene - 2 Sept 1994
Hawkins A R, Lamb H K, Radford A, Moore J D
Abstract excerpt
Studies on the quinic acid utilisation gene (qut) cluster in Aspergillus nidulans showed that the genes encoding transcriptional activator and repressor proteins evolved by co-opting duplicated copies of genes encoding metabolic enzymes. In order to test the hypothesis that this was a general rou...
Topics
- Aspergillus nidulans
- Biological Evolution
- Conserved Sequence
- DNA-Binding Proteins
- Ethanol
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, Regulator
- Glutamine
- Molecular Sequence Data
- Mutation
- Neurospora crassa
- Nitrogen
- Quaternary Ammonium Compounds
- Saccharomyces cerevisiae
- Sequence Alignment
- Sequence Homology, Amino Acid