Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia.

doi:10.1042/bj3010661

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Article

Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia.

The Biochemical journal - 1 Aug 1994

Treves S, Larini F, Menegazzi P, Steinberg T H, Koval M, Vilsen B, Andersen J P, Zorzato F

Abstract excerpt

Malignant hyperthermia (MH), an inherited neuromuscular disease triggered by halogenated inhalational anaesthetics and skeletal-muscle relaxants, appears to be due to an alteration of intracellular Ca2+ homoeostasis. MH occurs in 1 out of 20,000 anaesthetized adults and is characterized by hypermetabolism, skeletal-muscle rigidity and elevation in body temperature, which is frequently fatal [MacLennan and...

Topics

Amino Acid Sequence
Avian Sarcoma Viruses
Base Sequence
Blotting, Western
Calcium
Calcium Channels
Cell Line
DNA, Complementary
Fluorescent Antibody Technique
Malignant Hyperthermia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Muscle Proteins

Muscles

Mutation

Promoter Regions, Genetic

Repetitive Sequences, Nucleic Acid

Restriction Mapping

Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 8053891
DOI: 10.1042/bj3010661
PMCID: PMC1137039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8053891-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia.PMID 8053891Read ↗

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