Genetics and multiple sclerosis: an overview.

Abstract excerpt

There is evidence to support the view that multiple sclerosis is a complex trait determined by both genetic and environmental factors. The genetic component is reflected in the higher rate of concordance in monozygotic versus dizygotic twins and in familial recurrence risk data. These data fit best with oligogenic hypotheses encompassing epistatic interactions. However, confirmation will require comprehensive...

Topics

• Adult
• Alleles
• Diseases in Twins
• Environment
• Family
• Female
• Gene Frequency
• Genetic Linkage
• Genetic Markers
• Humans
• Male
• Middle Aged
• Models, Genetic