Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency.

The Journal of endocrinology - 1 Apr 1994

Beamer W G, Sweet H O, Bronson R T, Shire J G, Orth D N, Davisson M T

Abstract excerpt

A spontaneous autosomal recessive mutation causing disordered morphogenesis of the adrenal cortex has been identified in DW/J inbred strain mice and named adrenocortical dysplasia (acd). The acd mutant gene has been mapped just proximal to oligosyndactyly (Os) and esterase-1 (Es-1) in the central region of chromosome 8. Both male and female acd/acd mice are characterized by reduced survival, retarded growth, skin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Chromosome Mapping
Share to Genes, Recessive

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homozygote

Share to Mice, Mutant Strains

Share to Microscopy, Electron

Share to Phenotype

Source

Identifiers

PMID: 8014601
DOI: 10.1677/joe.0.1410033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency.PMID 8014601Read ↗

IMAGe association and congenital adrenal hypoplasia: no disease-causing mutations found in the ACD gene.Semantic proximity Read ↗

SF-1, DAX-1, and acd: molecular determinants of adrenocortical growth and steroidogenesis.Semantic proximity Read ↗

Adrenal Cortex Development and Maintenance: Knowledge Acquired From Mouse ModelsSemantic proximity Read ↗

Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.Semantic proximity Read ↗

Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.Semantic proximity Read ↗

Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci.Semantic proximity Read ↗

Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.Semantic proximity Read ↗

Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasiaSemantic proximity Read ↗

Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response.Semantic proximity Read ↗

Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation.Semantic proximity Read ↗

Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromes.Semantic proximity Read ↗

Quantitative trait locus mapping of genes associated with vacuolation in the adrenal X-zone of the DDD/Sgn inbred mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.