The imprecision in rates of down syndrome by 1‐year maternal age intervals: A critical analysis of rates used in biochemical screening

Abstract excerpt

Current algorithms to determine eligibility for prenatal cytogenetic diagnostic services depend critically on the accuracy and precision of the underlying rates of cytogenetic abnormality used in the calculations. We examine the maternal age-specific rates of Down syndrome livebirths in eight studies of European-origin populations, pooled rates from which are widely used for baseline calculations in biochemical...

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