Article
Requirement of casein kinase II-mediated phosphorylation for the transcriptional activity of human respiratory syncytial viral phosphoprotein P: transdominant negative phenotype of phosphorylation-defective P mutants.
Virology - 15 Nov 1994
Mazumder B, Barik S
Abstract excerpt
The transcription complex of the human respiratory syncytial virus was biochemically dissected and reconstituted in vitro with purified viral macromolecules. The minimal complex consisted of the viral N-RNA template, viral phosphoprotein (P), and the large protein (L) along with host cellular fac...
Topics
- Casein Kinase II
- HN Protein
- Humans
- Mutation
- Phenotype
- Phosphates
- Phosphorylation
- Protein Binding
- Protein Serine-Threonine Kinases
- Respiratory Syncytial Viruses
- Templates, Genetic
- Transcription, Genetic
- Tumor Cells, Cultured
- Viral Envelope Proteins
- Viral Proteins