Article
Epigenetic nature of radiation carcinogenesis at low doses.
Chinese medical journal - 1 Jun 1994
Sugahara T, Watanabe M
Abstract excerpt
The present paradigm of radiation-induced carcinogenesis has been based on somatic mutation theory initiating a mutation in somatic cells derived from DNA damage by ionizing radiation. A non-threshold linear model has been assumed from high doses to low doses. As an alternative to this, we are pr...
Topics
- Animals
- Cell Transformation, Neoplastic
- Cricetinae
- Cytokines
- DNA Damage
- Dose-Response Relationship, Radiation
- Embryo, Mammalian
- Mesocricetus
- Mutation
- Neoplasms, Radiation-Induced
- Radiation Dosage