Article
Localization of the gene encoding the alpha 2/delta-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families.
Human molecular genetics - 1 Jun 1994
Iles D E, Lehmann-Horn F, Scherer S W, Tsui L C, Olde Weghuis D, Suijkerbuijk R F, Heytens L, Mikala G, Schwartz A, Ellis F R
Abstract excerpt
Malignant hyperthermia susceptibility (MHS) is an autosomal dominant disorder of skeletal muscle which manifests as a potentially fatal hypermetabolic crisis triggered by commonly used anaesthetic agents. The demonstration of genetic heterogeneity in MHS prompted the investigation of the roles pl...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Calcium Channels
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Chromosomes, Human, Pair 7
- Cloning, Molecular
- DNA Primers
- DNA, Satellite
- Europe
- Female
- Genetic Linkage