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Article

Biochemical and molecular characterization of a new sporadic glucose-6-phosphate dehydrogenase variant described in Italy: G6PD Modena.

British journal of haematology - 1 May 1994

Cappellini M D, Sampietro M, Toniolo D, Carandina G, Pittalis S, Martinez di Montemuros F, Tavazzi D, Fiorelli G

Abstract excerpt

A new glucose-6-phosphate dehydrogenase variant detected in an Italian man from the Po delta is described and designated as G6PD Modena. Biochemical characterization of the variant enzyme revealed an activity 21% of normal, a slow electrophoretic mobility, increased Km value for NADP, decreased Km value for G6P and a complete absence of NADPH inhibition, which could account for the apparently nonhaemolytic...

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Identifiers

PMID: 7947250
DOI: 10.1111/j.1365-2141.1994.tb04896.x

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