Phenotypic and functional modulation of normal human alveolar macrophages by histamine.

doi:10.1165/ajrcmb.11.4.7917313

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Article

Phenotypic and functional modulation of normal human alveolar macrophages by histamine.

American journal of respiratory cell and molecular biology - 1 Oct 1994

Vignola A M, Chanez P, Paul-Lacoste P, Paul-Eugène N, Godard P, Bousquet J

Abstract excerpt

Alveolar macrophages (AM) play a regulatory role in asthma. AM from asthmatics are activated, release increased amounts of cytokines, and express higher levels of the low affinity receptor for IgE (Fc epsilon RIIb/CD23b) and receptors for adhesion molecules. The bronchial microenvironment may modulate the phenotypic and functional characteristics of AM. On AM from normal subjects, the effects of histamine were...

Topics

Adult
Aged
Asthma
Bronchoalveolar Lavage Fluid
Cells, Cultured
Cycloheximide
Dose-Response Relationship, Drug
Drug Interactions
Enzyme-Linked Immunosorbent Assay
Female
Fibronectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histamine

Humans

Immunoenzyme Techniques

Immunohistochemistry

Intercellular Adhesion Molecule-1

Lymphocyte Function-Associated Antigen-1

Macrophages, Alveolar

Source

Open in PubMed

Identifiers

PMID: 7917313
DOI: 10.1165/ajrcmb.11.4.7917313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7917313-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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