Nondetectability of restriction fragments and independence of DNA fragment sizes within and between loci in RFLP typing of DNA.

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Article

Nondetectability of restriction fragments and independence of DNA fragment sizes within and between loci in RFLP typing of DNA.

American journal of human genetics - 1 Aug 1994

Chakraborty R, Zhong Y, Jin L, Budowle B

Abstract excerpt

We provide experimental evidence showing that, during the restriction-enzyme digestion of DNA samples, some of the HaeIII-digested DNA fragments are small enough to prevent their reliable sizing on a Southern gel. As a result of such nondetectability of DNA fragments, individuals who show a single-band DNA profile at a VNTR locus may not necessarily be true homozygotes. In a population database, when the presence...

Topics

Alleles
Chi-Square Distribution
DNA Fingerprinting
Databases, Factual
Deoxyribonucleases, Type II Site-Specific
Ethnicity
Forensic Medicine
Gene Frequency
Genetic Variation
Genotype
Government Agencies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Likelihood Functions

Models, Genetic

Police

Polymorphism, Restriction Fragment Length

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7913584
PMCID: PMC1918372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7913584-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Nondetectability of restriction fragments and independence of DNA fragment sizes within and between loci in RFLP typing of DNA.PMID 7913584Read ↗

Correlation of DNA fragment sizes within loci in the presence of non-detectable alleles.Semantic proximity Read ↗

Physical properties of VNTR data, and their impact on a test of allelic independence.Semantic proximity Read ↗

Testing independence of fragment lengths within VNTR loci.Semantic proximity Read ↗

Apparent heterozygote deficiencies observed in DNA typing data and their implications in forensic applications.Semantic proximity Read ↗

Estimation of allele frequencies for VNTR loci.Semantic proximity Read ↗

A note on Hardy-Weinberg equilibrium of VNTR data by using the Federal Bureau of Investigation's fixed-bin method.Semantic proximity Read ↗

Testing Hardy-Weinberg equilibrium on allelic data from VNTR loci.Semantic proximity Read ↗

A test of allelic independence based on distributions of allele size differences at microsatellite loci.Semantic proximity Read ↗

Independence of VNTR alleles defined as floating bins.Semantic proximity Read ↗

Exact tests for association between alleles at arbitrary numbers of loci.Semantic proximity Read ↗

The limits of individual identification from sample allele frequencies: theory and statistical analysis.Semantic proximity Read ↗

Prevention of false results from preferential PCR amplification or VNTR alleles.Semantic proximity Read ↗

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