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Article

Nondetectability of restriction fragments and independence of DNA fragment sizes within and between loci in RFLP typing of DNA.

American journal of human genetics - 1 Aug 1994

Chakraborty R, Zhong Y, Jin L, Budowle B

Abstract excerpt

We provide experimental evidence showing that, during the restriction-enzyme digestion of DNA samples, some of the HaeIII-digested DNA fragments are small enough to prevent their reliable sizing on a Southern gel. As a result of such nondetectability of DNA fragments, individuals who show a single-band DNA profile at a VNTR locus may not necessarily be true homozygotes. In a population database, when the presence...

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Identifiers

PMID: 7913584
PMCID: PMC1918372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nondetectability of restriction fragments and independence of DNA fragment sizes within and between loci in RFLP typing of DNA.PMID 7913584Read ↗

Correlation of DNA fragment sizes within loci in the presence of non-detectable alleles.Semantic proximity Read ↗

Physical properties of VNTR data, and their impact on a test of allelic independence.Semantic proximity Read ↗

Testing independence of fragment lengths within VNTR loci.Semantic proximity Read ↗

Apparent heterozygote deficiencies observed in DNA typing data and their implications in forensic applications.Semantic proximity Read ↗

Estimation of allele frequencies for VNTR loci.Semantic proximity Read ↗

A note on Hardy-Weinberg equilibrium of VNTR data by using the Federal Bureau of Investigation's fixed-bin method.Semantic proximity Read ↗

Testing Hardy-Weinberg equilibrium on allelic data from VNTR loci.Semantic proximity Read ↗

A test of allelic independence based on distributions of allele size differences at microsatellite loci.Semantic proximity Read ↗

Independence of VNTR alleles defined as floating bins.Semantic proximity Read ↗

Exact tests for association between alleles at arbitrary numbers of loci.Semantic proximity Read ↗

The limits of individual identification from sample allele frequencies: theory and statistical analysis.Semantic proximity Read ↗

Prevention of false results from preferential PCR amplification or VNTR alleles.Semantic proximity Read ↗

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