Hepatic accumulation of alpha-1-antitrypsin in chronic liver disease in the dog.

Abstract excerpt

Alpha-1-antitrypsin deficiency has long been known to cause liver cirrhosis in man, but whether it does so in the dog is uncertain. To investigate this point 57 dogs with clinically and histopathologically diagnosed chronic liver disease were examined. Isoelectric focusing of blood serum from these dogs and from 25 clinically healthy dogs revealed three different types of alpha-1 antitrypsin, designated F(fast),...

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