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Comparative analysis of human DNA variations by fluorescence-based sequencing of PCR products.

Genomics - 1 Sept 1994

Kwok P Y, Carlson C, Yager T D, Ankener W, Nickerson D A

Abstract excerpt

Automated, direct cycle sequencing of purified double-stranded PCR products using Taq polymerase and fluorescently labeled dideoxynucleotide terminators provides a robust and highly reproducible method for identifying DNA sequence variations in sequence-tagged sites. We describe a simple and sensitive strategy that reliably detects the presence of DNA variations when sequencing traces from several different...

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PMID: 7829062
DOI: 10.1006/geno.1994.1469

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