Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization.

doi:10.1002/jbmr.5650091007

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Article

Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 1994

Hirakawa K, Hirota S, Ikeda T, Yamaguchi A, Takemura T, Nagoshi J, Yoshiki S, Suda T, Kitamura Y, Nomura S

Abstract excerpt

The expression of the mRNAs for osteonectin (ON), osteopontin (OPN), osteocalcin (OC), and matrix Gla protein (MGP) was studied by in situ hybridization during the healing process of an experimental fracture in adult rat femora. At day 1 postoperatively, ON mRNA was detected in the proliferating periosteum. At day 3, ON, OPN, and OC mRNAs were detected in woven bone. From day 5, MGP and ON mRNAs were detected in...

Topics

Animals
Blotting, Northern
Bone and Bones
Calcium-Binding Proteins
Cartilage
Cell Division
Disease Models, Animal
Extracellular Matrix Proteins
Female
Femoral Fractures

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fracture Healing

Gene Expression Regulation, Developmental

Glycoproteins

In Situ Hybridization

Osteoblasts

Osteocalcin

Osteonectin

Osteopontin

Source

Open in PubMed

Identifiers

PMID: 7817800
DOI: 10.1002/jbmr.5650091007

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7817800-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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