Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site.

Abstract excerpt

Epstein-Barr virus (EBV) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as CD48, characteristically expressed on normal activated B cells. Here, we report on the identification of an enhancer element in the CD48 gene...

Topics

• Antigens, CD
• B-Lymphocytes
• Base Sequence
• CD48 Antigen
• Cell Line
• Cell Transformation, Viral
• Deoxyribonuclease I
• Enhancer Elements, Genetic
• Herpesvirus 4, Human
• Humans
• Molecular Sequence Data
• Mutation
• NF-kappa B