Article
Allele-specific quantification of Drosophila engrailed and invected transcripts.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 1994
Goldsborough A S, Kornberg T B
Abstract excerpt
Changes in levels of transcription can be difficult to gauge in animals with lethal mutations. For example, mutations in a regulatory region of an essential gene can have secondary consequences that complicate attempts to quantify the transcripts produced by the mutant gene. We describe a method that circumvents this problem by revealing the relative amount of transcript produced from each allele in a...
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