Article
Ancestral differences in the distribution of the delta 2642 glutamic acid polymorphism is associated with varying CAG repeat lengths on normal chromosomes: insights into the genetic evolution of Huntington disease.
Human molecular genetics - 1 Feb 1995
Almqvist E, Spence N, Nichol K, Andrew S E, Vesa J, Peltonen L, Anvret M, Goto J, Kanazawa I, Goldberg Y P
Abstract excerpt
This study addresses genetic factors associated with normal variation of the CAG repeat in the Huntington disease (HD) gene. To achieve this, we have studied patterns of variation of three trinucleotide repeats in the HD gene including the CAG and adjacent CCG repeats as well as a GAG polymorphism at residue 2642 (delta 2642). We have previously demonstrated that variation in the CCG repeat is associated with...
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