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Article

[Hb M-Iwate [alpha 87 (F8) His-->Tyr]: analysis of the genomic DNA and biosynthesis].

Rinsho byori. The Japanese journal of clinical pathology - 1 Mar 1995

Orisaka M, Sasaki T, Kato J, Harano K, Harano T

Abstract excerpt

Hb M-Iwate [alpha 87 (F8) His-->Tyr] was identified as the cause of cyanosis in a 21-year-old Japanese female. Amplification and sequencing of the alpha 2- and alpha 1-genes demonstrated the mutation CD87 CAC (His)-->TAC (Tyr) in the alpha 2-gene. Analysis of the in vitro globin biosynthesis in the reticulocytes disclosed a well-balanced beta/alpha synthetic ratio of 1.04 but an unexpectedly low alpha M/total...

Topics

Adult
Amino Acid Sequence
Base Sequence
Cyanosis
Female
Hemoglobin M
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Reticulocytes

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PMID: 7745837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7745837-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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