Fine mapping of Best's macular dystrophy localizes the gene in close proximity to but distinct from the D11S480/ROM1 loci.

doi:10.1006/geno.1994.1648

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Article

Fine mapping of Best's macular dystrophy localizes the gene in close proximity to but distinct from the D11S480/ROM1 loci.

Genomics - 1 Dec 1994

Graff C, Forsman K, Larsson C, Nordström S, Lind L, Johansson K, Sandgren O, Weissenbach J, Holmgren G, Gustavson K H

Abstract excerpt

The Best's macular dystrophy (BMD) gene has previously been mapped to the 11q13 region. In this study, recombination data localizes the BMD gene to the 6-cM genetic interval between the markers Fc epsilon RI and D11S480/ROM1 in a large Swedish 12-generation BMD family. Mutation analyses of the ca...

Topics

Alleles
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 11
DNA Primers
DNA, Satellite
Female
Gene Frequency
Genetic Linkage
Genetic Markers
Humans
Macular Degeneration
Male
Molecular Sequence Data
Pedigree
Recombination, Genetic
Sweden

Source

Open in PubMed

Identifiers

PMID: 7713492
DOI: 10.1006/geno.1994.1648

Genes

ROM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7713492-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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