Article
[A mathematical model of the status of mitochondrial DNA for assessing the effectiveness of energy biosynthesis in mammalian cells].
Biofizika - 1 Jan 2000
Beregovskaia N N, Maĭboroda R E, Skorbun A D
Abstract excerpt
A concept is advanced according to which the processes of ageing, non-specific pathology and malignant transformation are caused by mutations of mitochondrial DNA which controls protein synthesis of the oxidation phosphorylation system. A mathematical model is plotted for describing the efficiency of the system of energy supply of mammalian cells as a function of accumulation of mtDNA mutations. It is shown that...
Topics
- Animals
- Cell Transformation, Neoplastic
- DNA, Mitochondrial
- Energy Metabolism
- Mammals
- Models, Theoretical
- Mutation
- Oxidative Phosphorylation
- Protein Biosynthesis