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Article

Extended haplotype analysis of cystic fibrosis mutations and its implications for the selective advantage hypothesis.

Human genetics - 1 Oct 1993

Sereth H, Shoshani T, Bashan N, Kerem B S

Abstract excerpt

The major cystic fibrosis (CF) mutation, delta F508, is associated with one haplotype (B) determined by the two polymorphic markers, XV2C and KM19. This haplotype is rare (15%) among non-CF chromosomes. Its frequency among non-delta F508 CF chromosomes is 50% with variation between populations. One hypothesis for the high frequency of CF haplotype B chromosomes suggests that there was a selective advantage for CF...

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PMID: 7691712
DOI: 10.1007/BF00244474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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