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Article

Neonatal screening for cystic fibrosis: addition of molecular diagnostics to increase specificity.

Biochemical medicine and metabolic biology - 1 Apr 1993

Spence W C, Paulus-Thomas J, Orenstein D M, Naylor E W

Abstract excerpt

Newborn screening for cystic fibrosis (CF) has been carried out on approximately 106,000 neonates in western Pennsylvania since 1987 using the immunoreactive trypsinogen (IRT) assay on dried filter paper blood specimens (DBS). Molecular analysis utilizing a duplicate DBS from the same sample was implemented in November 1989 for newborns having elevated IRT levels. DNA is amplified directly from the DBS and the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 7683477
DOI: 10.1006/bmmb.1993.1022

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UNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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