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Article

A metabolic study of the activity of GDP-mannose dehydrogenase and concentrations of activated intermediates of alginate biosynthesis in Pseudomonas aeruginosa.

Journal of general microbiology - 1 Jan 1993

Tatnell P J, Russell N J, Gacesa P

Abstract excerpt

GDP-mannose dehydrogenase (GMD) is a key regulatory enzyme and the committal step in alginate biosynthesis. In this study, a metabolic approach has been used to investigate GMD activity in non-mucoid and isogenically related mucoid strains of Pseudomonas aeruginosa. Intracellular concentrations of GDP-mannose and GDP-mannuronate have been quantified using HPLC separation methods, and their concentrations have...

Topics

Alginates
Carbohydrate Dehydrogenases
Cell Extracts
Chromatography, High Pressure Liquid
Guanosine Diphosphate Mannose
Mutation
Nucleoside Diphosphate Sugars
Nucleotides
Polymorphism, Genetic
Pseudomonas aeruginosa

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Identifiers

PMID: 7680707
DOI: 10.1099/00221287-139-1-119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7680707-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A metabolic study of the activity of GDP-mannose dehydrogenase and concentrations of activated intermediates of alginate biosynthesis in Pseudomonas aeruginosa.PMID 7680707Read ↗

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