A Tsp509I variant in exon 13 of the neurofibromatosis type 1 (NF1) gene allows the identification of both alleles at the mRNA level.

doi:10.1007/BF00214202

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Article

A Tsp509I variant in exon 13 of the neurofibromatosis type 1 (NF1) gene allows the identification of both alleles at the mRNA level.

Human genetics - 1 Jul 1995

Régnier V, Danglot G, Nguyen V C, Bernheim A

Abstract excerpt

We describe here a new sequence variant occurring in the coding region of the neurofibromatosis (NF1) gene (exon 13). This exonic polymorphism can be directly investigated by simple restriction enzyme digestion of RT-PCR (reverse transcription-polymerase chain reaction) products, making it a powe...

Topics

Alleles
Base Sequence
Exons
Humans
Molecular Sequence Data
Neurofibromatosis 1
Polymerase Chain Reaction
Polymorphism, Genetic
RNA, Messenger
RNA, Neoplasm

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