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Article

The Bloom's syndrome gene product is homologous to RecQ helicases.

Cell - 17 Nov 1995

Ellis N A, Groden J, Ye T Z, Straughen J, Lennon D J, Ciocci S, Proytcheva M, German J

Abstract excerpt

The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A candidate for BLM was identified by direct selection of a cDNA derived from a 250 kb segment of the genome to which BLM had been assigned by somatic crossover point mapping. In this novel mapping method, cells were used from persons with BS that had undergone intragenic recombination within...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7585968
DOI: 10.1016/0092-8674(95)90105-1

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The Bloom's syndrome gene product is homologous to RecQ helicases.PMID 7585968Read ↗

Molecular genetics of Bloom's syndrome.Semantic proximity Read ↗

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Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry.Semantic proximity Read ↗

A novel frameshift mutation in BLM gene associated with high sister chromatid exchanges (SCE) in heterozygous family members.Semantic proximity Read ↗

Role of the Bloom's syndrome helicase in maintenance of genome stability.Semantic proximity Read ↗

Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.Semantic proximity Read ↗

Missing heritability in Bloom syndrome: First report of a deep intronic variant leading to pseudo-exon activation in the BLM gene.Semantic proximity Read ↗

Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

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