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Eleven novel mutations in the factor VIII gene from Brazilian hemophilia A patients.

Blood - 15 Oct 1995

Arruda V R, Pieneman W C, Reitsma P H, Deutz-Terlouw P P, Annichino-Bizzacchi J M, Briët E, Costa F F

Abstract excerpt

The molecular characterization of the mutations in hemophilia A patients is hampered by the large size of the factor VIII gene and the great heterogeneity of mutations. In this study, we have performed a protocol involving multiplex polymerase chain reaction in which 19 exons were amplified in four different combinations followed by nonradioactive single-strand conformational polymorphism (SSCP) to screen for...

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PMID: 7579394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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