Article
Chronic leukocytoclastic vasculitis complicating HBV infection. Possible role of mutant forms of HBV in pathogenesis and persistence of disease.
Journal of clinical gastroenterology - 1 Jul 1995
Bonkovsky H L, Liang T J, Hasegawa K, Banner B
Abstract excerpt
A young woman developed arthritis and leukocytoclastic vasculitis, followed by hepatitis due to a precore mutant strain of hepatitis B virus (HBV) incapable of synthesizing HBe antigen. Tests for antibodies to HCV were persistently negative. Treatment of the patient with alpha interferon initially led to a severe exacerbation of hepatitis. Later, higher doses of interferon were tolerated and were associated with...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Chronic Disease
- DNA, Viral
- Female
- Hepatitis B
- Hepatitis B virus
- Humans
- Interferon-alpha
- Molecular Sequence Data