Article
Abnormal keratin 1 and 10 cytoskeleton in cultured keratinocytes from epidermolytic hyperkeratosis caused by keratin 10 mutations.
The Journal of investigative dermatology - 1 May 1994
Huber M, Scaletta C, Benathan M, Frenk E, Greenhalgh D A, Rothnagel J A, Roop D R, Hohl D
Abstract excerpt
Epidermolytic hyperkeratosis is caused by mutations of the differentiation-specific keratins K1 and K10. These mutations produce a weakened cytoskeleton that is prone to collapse resulting in cell fragility and lysis. In this study we have analyzed cultured keratinocytes from EHK patients bearing...
Topics
- Base Sequence
- Cell Division
- Cells, Cultured
- Cytoskeleton
- Humans
- Hyperkeratosis, Epidermolytic
- Keratin-10
- Keratinocytes
- Keratins
- Molecular Sequence Data
- Mutation
- RNA, Messenger