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Article

A domain of murine retrovirus surface protein gp70 mediates cell fusion, as shown in a novel SC-1 cell fusion system.

Journal of virology - 1 May 1994

Andersen K B

Abstract excerpt

Virus-induced cell fusion of the fusion-from-without type was observed in SC-1 cells infected with Moloney murine leukemia virus when grown in NIH 3T3 cells. Replication-competent virus mutants with altered surface protein gp70 were examined. Fusion mutations were found in the proline-rich region of gp70. They acted on a step after binding and before or during endocytosis. The fusion mutants had an altered gp70...

Topics

3T3 Cells
Acute-Phase Proteins
Animals
Antibodies, Viral
Cell Fusion
DNA Mutational Analysis
Endocytosis
Glycoproteins
Glycosylation
Mice
Moloney murine leukemia virus
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polysaccharides

Retroviridae Proteins, Oncogenic

Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7512160
DOI: 10.1128/JVI.68.5.3175-3182.1994
PMCID: PMC236808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7512160-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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