Article
Familial focal glomerulosclerosis: a genetic linkage to the HLA locus?
American journal of nephrology - 1 Jan 1995
Goodman D J, Clarke B, Hope R N, Miach P J, Dawborn J K
Abstract excerpt
The aetiology and pathogenesis of focal glomerulosclerosis is poorly understood and many conflicting reports suggest HLA locus associations in both familial and non-familial glomerulosclerosis. We report a family in which 4 of 5 sisters developed proteinuria, 2 with hypertension and 1 progressing...
Topics
- Adolescent
- Alleles
- Chromosome Mapping
- Family Health
- Female
- Genetic Linkage
- Glomerulosclerosis, Focal Segmental
- HLA Antigens
- HLA-A1 Antigen
- HLA-B8 Antigen
- HLA-DR3 Antigen
- HLA-DR7 Antigen
- Humans