Article
Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 1995
Garnero P, Borel O, Sornay-Rendu E, Delmas P D
Abstract excerpt
Bone mineral density (BMD) is under strong genetic control. Polymorphisms at the vitamin D receptor (VDR) gene have been recently suggested to account for up to 75% of this genetic effect. We analyzed these polymorphisms, i.e., that of BsmI, TaqI, and ApaI restriction enzymes by PCR of the DNA in 189 healthy premenopausal women aged 31 to 57 years. For the BsmI polymorphism they were 17% BB homozygotes, 51% Bb...
Topics
- Adult
- Bone Density
- Bone Resorption
- Female
- Genotype
- Humans
- Middle Aged
- Polymorphism, Genetic
- Premenopause
- Prognosis
- Prospective Studies
