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Article

Mammalian mitochondrial intermediate peptidase: structure/function analysis of a new homologue from Schizophyllum commune and relationship to thimet oligopeptidases.

Genomics - 10 Aug 1995

Isaya G, Sakati W R, Rollins R A, Shen G P, Hanson L C, Ullrich R C, Novotny C P

Abstract excerpt

Mitochondrial intermediate peptidase (MIP) is a component of the mitochondrial protein import machinery required for maturation of nuclear-encoded precursor proteins targeted to the mitochondrial matrix or inner membrane. We previously characterized this enzyme in rat (RMIP) and Saccharomyces cerevisiae (YMIP) and showed that MIP activity is essential for mitochondrial function in yeast. We have now defined the...

Topics

Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
DNA, Fungal
Fungal Proteins
Mammals
Metalloendopeptidases
Molecular Sequence Data
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Precursors

Rats

Saccharomyces cerevisiae

Schizophyllum

Sequence Homology, Amino Acid

Source

Identifiers

PMID: 7490080
DOI: 10.1006/geno.1995.1174

Genes

MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7490080-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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