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Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration

23 Dec 2015

Abstract excerpt

Mitochondrial dysfunction and altered proteostasis are central features of neurodegenerative diseases. The pitrilysin metallopeptidase 1 (PITRM1) is a mitochondrial matrix enzyme, which digests oligopeptides, including the mitochondrial targeting sequences that are cleaved from proteins imported across the inner mitochondrial membrane and the mitochondrial fraction of amyloid beta (Aβ). We identified two siblings...

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PMID: 26697887
DOI: 10.15252/emmm.201505894

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