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Article

Two novel polyadenylation mutations leading to beta(+)-thalassemia.

British journal of haematology - 1 May 1990

Jankovic L, Efremov G D, Petkov G, Kattamis C, George E, Yang K G, Stoming T A, Huisman T H

Abstract excerpt

In an ongoing effort to identify point mutations causing beta-thalassaemia, we have found two previously unreported mutations which are located in the Poly A site of the beta-globin gene. The screening programme used amplified DNA and dot-blot hybridization with several 32P-labelled oligonucleotide probes. DNA samples which remained unidentified by this methodology were subjected to sequencing with 32P-labelled...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Child
Child, Preschool
DNA Mutational Analysis
Family
Female
Globins
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Poly A

Thalassemia

Source

Identifiers

PMID: 2375910
DOI: 10.1111/j.1365-2141.1990.tb02627.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2375910-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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