Article
Epidemiological Investigation of Sex Differences by Cleft Phenotype and Extent in Cleft Lip and/or Palate: The Cohort Study of 4548 Japanese Patients.
Congenital anomalies - 1 Jan 2026
Yanagisawa Hiroaki, Niimi Teruyuki, Umeda Masahiro, Arasaki Akira, Nagase Yosikazu, Nakahara Shinichi, Yosida Maya, Fujiwara Kumiko, Sakuma Chisato, Kitagawa Ken, Akashi Junko, Akiyama Yuki, Hayami Kayo, Osakabe Rie, Natsume Nagana, Huang Wei-Lun, Saitou Naoki, Natsume Nagato, Yanagisawa Shigetaka
Abstract excerpt
Cleft lip and/or palate (CL/P) shows well-recognized sex differences, with a male predominance in cleft lip (CL) and cleft lip and palate (CLP), and a female predominance in isolated cleft palate (CP). However, how these differences vary according to detailed cleft patterns and extent remains unclear. This retrospective observational study included 4548 patients with CL/P treated at the cleft lip and palate...
Read the complete abstract on PubMedTopics
- Humans
- Cleft Lip
- Cleft Palate
- Male
- Female