[Efficacy and safety analysis of neoadjuvant avapritinib in patients with platelet-derived growth factor receptor α D842V-mutant gastrointestinal stromal tumors].

doi:10.3760/cma.j.cn441530-20250928-00367

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Article

[Efficacy and safety analysis of neoadjuvant avapritinib in patients with platelet-derived growth factor receptor α D842V-mutant gastrointestinal stromal tumors].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery - 25 Aug 2026

Zhang P, Zhou Y, Li J, Tian H K, Gao Z D, Qiu H B, Wu X Y, Jiao X L, Tao K X

Abstract excerpt

Objective: To evaluate the efficacy of avapritinib as neoadjuvant therapy in gastrointestinal stromal tumor (GIST) with platelet-derived growth factor receptor α (PDGFRA)- D842V mutation. Methods: We conducted a retrospective analysis of patients with gastrointestinal stromal tumors harboring the PDGFRA-D842V mutation who received neoadjuvant treatment with avapritinib. Clinical and pathological data were...

Read the complete abstract on PubMed

Topics

Humans
Gastrointestinal Stromal Tumors
Avapritinib
Neoadjuvant Therapy
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Receptor, Platelet-Derived Growth Factor alpha

Mutation

Middle Aged

Gastrointestinal Neoplasms

Pyrazoles

Triazines

Pyrroles

Treatment Outcome

Aged

Source

Open in PubMed

Identifiers

PMID: 42706101
DOI: 10.3760/cma.j.cn441530-20250928-00367

Genes

PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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