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Article

Novel production of vinblastine by immobilized cultures of mutant strain of the endophytic Alternaria alternata.

World journal of microbiology & biotechnology - 2 Sept 2026

El-Sayed El-Sayed R, Abdelkader Rofaida S, Moustafa Heba S, Yousef Samah A, Taha Mohamed A, Ouda Sahar M

Abstract excerpt

Vinblastine is a clinically important anticancer alkaloid, and the development of efficient microbial production systems remains a promising strategy for improving its sustainable availability. In the present study, Alternaria alternata Mut-85 was evaluated for vinblastine production using immobilized fungal cultures. Five entrapment carriers, were compared using both spore and mycelium immobilization. Calcium...

Read the complete abstract on PubMed

Topics

Alternaria
Vinblastine
Mycelium
Alginates
Spores, Fungal
Cells, Immobilized

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hexuronic Acids

Culture Media

Biomass

Glucuronic Acid

Endophytes

Fermentation

Bioreactors

Mutation

Temperature

Source

Identifiers

PMID: 42684635
DOI: 10.1007/s11274-026-05220-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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