Article
Cross-Trait Genome-Wide Association Study Identifies Shared Genetic Architecture Between COPD and Retinal Vascular Phenotypes.
International journal of chronic obstructive pulmonary disease - 1 Jan 2026
Chen Yuli, Li Yibin, Tang Yijiao, Yuan XinQi, Chen Rui
Abstract excerpt
Background: Chronic obstructive pulmonary disease (COPD) is accompanied by systemic vascular dysfunction and microcirculatory impairment. Retinal vascular traits provide a non-invasive window into microvascular characteristics, although their shared genetic architecture with COPD remains unclear. Methods: We integrated genome-wide association study summary statistics for COPD and 17 retinal vascular traits in...
Read the complete abstract on PubMedTopics
- Humans
- Genome-Wide Association Study
- Pulmonary Disease, Chronic Obstructive
- Phenotype
- Polymorphism, Single Nucleotide