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Article

Metabolic syndrome identifies a high-risk polypharmacy phenotype in older adults with syncope.

Pharmacological research - 1 Oct 2026

Longo Susanna, Rizza Stefano, Fernández-Real Jose Manuel, Federici Massimo

Abstract excerpt

Syncope and polypharmacy are prevalent in older adults and negatively affect quality of life. This study compares the impact of medication regimen complexity, the total number of medications per day as a measure of polypharmacy, and orthostatic hypotension (OH)-inducing drug burden in older adults with syncope. It also sought to determine a polypharmacy threshold warranting medication review and to identify a...

Read the complete abstract on PubMed

Topics

Humans
Polypharmacy
Metabolic Syndrome
Aged
Syncope
Phenotype
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Hypotension, Orthostatic

Aged, 80 and over

Middle Aged

Risk Factors

Age Factors

Source

Identifiers

PMID: 42674124
DOI: 10.1016/j.phrs.2026.108426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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