Article
Case Report: From idiopathic recurrent pericarditis to systemic Behçet's Disease: unmasking a unified IL-1-driven autoinflammatory phenotype.
Frontiers in immunology - 1 Jan 2026
Emanuele Bizzi, Angela Mauro, Germinario Cristiano, Francesca Casarin, Silvia Berra, Stefano Ministrini, Antonio Gidaro, Giuseppina Manzotti, Maria Marra Alessandro, Sara Rotunno, Elisabetta Greco, Stella Modica, Francesco Paciullo, Martina Sculco, Sarah Damanti, Giulia Abatianni, Caterina Gagliardi, Patrizia Rovere Querini, Antonio Brucato
Abstract excerpt
Background: Recurrent idiopathic recurrent pericarditis (RP) is increasingly recognized as an organ-specific autoinflammatory syndrome driven by the interleukin-1 (IL-1) axis. Behçet's Disease (BD), a systemic vasculitis, exhibits significant pathogenetic overlap with RP through IL-1 mediated hyperinflammation, particularly in phenotypes dominated by serositis. The clinical evolution of prolonged, seemingly...
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