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Article

Phenotypic and biochemical characterization of the class C β-lactamase, PAC-1.

The Journal of antimicrobial chemotherapy - 4 Aug 2026

Raro Otávio Hallal Ferreira, Mancini Stefano, Findlay Jacqueline, Seth-Smith Helena M B, Ali Syed Muhammad, Egli Adrian, Nordmann Patrice, Poirel Laurent

Abstract excerpt

BACKGROUND: The class C β-lactamase, PAC-1, was originally described as acquired in Pseudomonas aeruginosa clinical isolates from south Asia, the corresponding gene being chromosomally located and embedded within a Tn1721-like transposon. Despite its association with high-level resistance to cephalosporins and β-lactam/β-lactamase inhibitor combinations, data on its full hydrolytic profile and kinetic parameters...

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beta-Lactamases
Azabicyclo Compounds
beta-Lactamase Inhibitors
beta-Lactams
Cephalosporins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Pseudomonas aeruginosa

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PMID: 42639739
DOI: 10.1093/jac/dkag291
PMCID: PMC13504281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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