Mendelian randomization study of smoking exposure in relation to primary ovarian failure.

Abstract excerpt

Although observational data suggest a relationship between primary ovarian insufficiency (POI) and smoking, there remain questions about causality. An unhealthy lifestyle, including smoking, can accelerate the depletion of the follicular pool and the early onset of menopause. Extensive research has been conducted on the detrimental effects of tobacco smoke on the ovaries. Mendelian randomization (MR) is a method...

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