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Article

Population-Level Nucleotide Diversity and Genetic Differentiation at SOD1 Across Global Human Populations.

Annals of human genetics - 1 Nov 2026

Flores Sergio V, Lillo Patricia, Briceño-Moya Jorge

Abstract excerpt

BACKGROUND: The SOD1 gene encodes superoxide dismutase 1, an antioxidant enzyme in which pathogenic variants cause a subset of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although the clinical and molecular consequences of SOD1 variants are well established, its locus-wide population genetic architecture has not been systematically characterized across global populations. OBJECTIVE: To...

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Identifiers

PMID: 42606140
DOI: 10.1111/ahg.70052

Genes

SOD1
FST

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