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Population‐Level Nucleotide Diversity and Genetic Differentiation at <i>SOD1</i> Across Global Human Populations

17 Aug 2026

Abstract excerpt

BACKGROUND: The SOD1 gene encodes superoxide dismutase 1, an antioxidant enzyme in which pathogenic variants cause a subset of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although the clinical and molecular consequences of SOD1 variants are well established, its locus-wide population genetic architecture has not been systematically characterized across global populations. OBJECTIVE: To...

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PMID: 42606140
DOI: 10.1111/ahg.70052

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