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Article

A proactive large platelet-driven screening strategy for the early recognition of MYH9-related disease: a Chinese prospective cohort study.

Research and practice in thrombosis and haemostasis - 1 Jul 2026

Chen Wenlan, Arif Abdul Rehman, Ding Yajie, Wang Limin, Cai Li, Arif Muneeba, Xue Mei, Mei Heng, Wang Yadan

Abstract excerpt

Background: Accurate diagnosis of MYH9-related disease (MYH9-RD) is frequently impeded by a reactive process. Clinical suspicion typically arises only following immune thrombocytopenia (ITP) treatment failure, family history identification, or emergence of extra-hematological manifestations. However, de novo variants or delayed syndromic onset may obscure these indicators, leading to misdiagnosis as ITP and...

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Blood Platelets
Early Diagnosis
East Asian People
Hearing Loss, Sensorineural
Molecular Motor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myosin Heavy Chains

Thrombocytopenia

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Identifiers

PMID: 42598527
DOI: 10.1016/j.rpth.2026.106824
PMCID: PMC13471207

Genes

MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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